As a neuroleptic agent in delusions & hallucinations in acute & chronic schizophrenia, paranoia, & acute confusion, alcoholism (Korsakoff's syndrome); hypochondriac delusions; personality disorders: paranoid, schizoid, schizotype, antisocial, some "borderline" & other personalities. As a psychomotor anti-agitation agent in mania, dementia, mental retardation, alcoholism; personality disorders: compulsive, paranoid, histrionic & other personalities; agitation, aggressiveness, & wandering impulsion in the elderly; disorders of behaviour & character in childn; choreatic movements; singultus (hiccup); tics, stuttering. As an adjuvant in the treatment of severe chronic pain.
AdultAcute episodes of schizophrenia, delirium tremens, paranoia, acute confusion, Korsakoff's syndrome, acute paranoia Nearly double the IM dose. IM dose: 5-10 mg IM, repeated hrly until sufficient control is achieved or up to max 60 mg/day. Chronic schizophrenia, chronic alcoholism, chronic personality disorders 1-3 mg tds; may be increased to 10-20 mg tds. Chronic phase of mania, dementia, alcoholism, personality disorders, behaviour & character disorders, singultus, choreatic movements, tics, stuttering 0.5-1 mg tds; may be increased to 2-3 mg tds if required. Adjuvant in chronic pain therapy 0.5-1 mg tds. Elderly Initially ½ adult dose, then adjust according to the response if required. Childn 0.1 mg/3 kg tds, may be adjusted if needed.
QT prolongation &/or ventricular arrhythmias; neuroleptic malignant syndrome; tardive dyskinesia on long-term therapy or after drug discontinuation; extrapyramidal symptoms; seizures; hormonal effects ie, hyperprolactinaemia which may cause galactorrhoea, gynaecomastia & oligo- or amenorrhoea; venous thromboembolism. Patients w/ hyperthyroidism. Response to treatment may be delayed in schizophrenia. Recurrence of symptoms may not become apparent for several wk or mth if drugs are withdrawn. Gradual w/drawal is advisable. Should not be used alone where depression is predominant. Patients w/ liver disease. Elderly patients w/ dementia-related psychosis. May affect ability to drive or operate machinery. Pregnancy & lactation.
Sign Out
